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She Wrote A Poem For Her Daughters
Cancer research depends on the use of human cell lines for both the in vitro culture and in vivo xenograft analysis of tumor progression and treatment. However, the extent to which cultured preparations of human cancer lines display similar properties in vivo , where important host factors may influence tumor biology, remains unclear. Here, we address this question by conducting a functional proteomic analysis of the human breast cancer line MDA-MB grown in culture and as orthotopic xenograft tumors in the mammary fad pad of immunodeficient mice. Using a suite of activity-based chemical probes, we identified carcinoma human enzyme activities that were expressed selectively in culture or in xenograft tumors. Likewise, distinct groups of stromal mouse enzyme activities were found that either infiltrated or were excluded from xenograft tumors, indicating a contribution by specific host components to breast cancer development. MDA-MB cells isolated from tumors exhibited profound differences in their enzyme activity profiles compared with the parent cell line, including the dramatic posttranscriptional up-regulation of the serine proteases urokinase plasminogen activator and tissue plasminogen activator and down-regulation of the glycolytic enzyme phosphofructokinase. These altered enzyme activity profiles correlated with significantly greater tumor growth rates and metastases for xenograft-derived MDA-MB cells upon reintroduction into mice.
Together we've funded 27, mammograms. Learn more. Veronica Waldrop started the poem for her daughter, hoping to inspire her to take pride in who she is. She finished it three years later, but during that time she was diagnosed with stage IV breast cancer. Her story is hearbreaking. Her last wish was to inspire. Becoming a medical illustrator requires a thorough knowledge of human anatomy and an artistic skill.
Micromastia also called hypomastia , breast aplasia , breast hypoplasia , or mammary hypoplasia is a medical term describing the postpubertal underdevelopment of a woman's breast tissue. Breast development is commonly asymmetric and one or both breasts may be small. This condition may be a congenital defect associated with underlying abnormalities of the pectoral muscle as in Poland's syndrome  , related to trauma typically surgery or radiotherapy or it may be a more subjective aesthetic description.